Collagen and related extracellular matrix proteins in atherosclerotic plaque development.
Curr Opin Lipidol
; 25(5): 394-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25137612
ABSTRACT
PURPOSE OF REVIEW The structure, composition and turnover of the extracellular matrix (ECM) as well as cell-matrix interactions are crucial in the developing atherosclerotic plaque. There is a need for further insight into specific proteins in the ECM and their functions in the developing plaque, and during the last few years a number of publications have highlighted this very important field of research. These novel findings will be addressed in the present review. RECENT FINDINGS:
This review covers literature focused on collagen and ECM proteins interacting with collagen, and what their roles may be in plaque development.SUMMARY:
Acute myocardial infarction and stroke are common diseases that cause disability and mortality, and the underlying mechanism is often the rupture of a vulnerable atherosclerotic plaque. The vascular ECM and the tissue repair in the atherosclerotic lesion are important players in plaque progression. Understanding how specific proteins in the ECM interact with cells in the plaque and affect the fate of the plaque can lead to new treatments for cardiovascular disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas da Matriz Extracelular
/
Colágeno
/
Aterosclerose
/
Placa Aterosclerótica
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Lipidol
Ano de publicação:
2014
Tipo de documento:
Article