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Mannosylated lipoarabinomannan in serum as a biomarker candidate for subclinical bovine tuberculosis.
Lamont, Elise A; Ribeiro-Lima, João; Waters, Wade Ray; Thacker, Tyler; Sreevatsan, Srinand.
Afiliação
  • Sreevatsan S; Department of Veterinary Population Medicine, University of Minnesota, St, Paul, Minnesota, USA. sreev001@umn.edu.
BMC Res Notes ; 7: 559, 2014 Aug 21.
Article em En | MEDLINE | ID: mdl-25146892
ABSTRACT

BACKGROUND:

Early and unambiguous detection of bovine tuberculosis (bTB), a significant disease of cattle worldwide, is necessary to control the spread of infection to other animals and humans. Current testing strategies are laborious, time consuming and heavily reliant on host responses that do not distinguish bTB from other mycobacteria. We report the presence of a pathogen signature, liparabinomannan (LAM), as a potential biomarker for bTB infection.

FINDINGS:

Fifty-five animals (uninfected [n = 33], bTb [n = 10] and exposed cases [n = 12]) from a well characterized bovine serum repository were screened for the presence of LAM using a commercially available ELISA. Analysis showed that LAM had a sensitivity of 100% and a specificity of 91.7% for bTB detection (bTB positive versus bTB exposed animals).

CONCLUSION:

LAM detection easily separated bTB infected animals from bTB exposed and negative controls. We propose that pathogen related markers, such as LAM, should be included with current testing strategies as a battery diagnostic for bTB.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Tuberculose Bovina / Biomarcadores / Lipopolissacarídeos / Manose Limite: Animals Idioma: En Revista: BMC Res Notes Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Tuberculose Bovina / Biomarcadores / Lipopolissacarídeos / Manose Limite: Animals Idioma: En Revista: BMC Res Notes Ano de publicação: 2014 Tipo de documento: Article