Down-regulated expression of NPM1 in IMS-M2 cell line by (-)-epigallocatechin-3-gallate.
Asian Pac J Trop Biomed
; 4(7): 570-4, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-25183279
ABSTRACT
OBJECTIVE:
To investigate the inhibited effect of epigallocatechin-3-gallate (EGCG) on the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations.METHODS:
Cell proliferation assay was performed to test the effects of EGCG on cell growth of IMS-M2 cells harboring the NPM1 mutations. Western blot analysis were performed to test the protein expression of NPM1, AKT, those associated with apoptosis.RESULTS:
EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations. Moreover, EGCG also suppressed the cell proliferation and induced apoptosis in IMS-M2 cells.CONCLUSIONS:
The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Asian Pac J Trop Biomed
Ano de publicação:
2014
Tipo de documento:
Article