Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvß8 with type â
collagen.
Int J Oncol
; 45(5): 1875-82, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25190218
ABSTRACT
To examine the role of integrin αv subunit in the progression of squamous cell carcinoma (SCC), oral SCC cells were stably transfected with integrin αv cDNA. Integrin αv transfectants exhibited the enhancement of proliferation on type â
collagen, and seemed to have a high ability to invade type â
collagen gel. Overexpression of integrin αv led to rapid phosphorylation of focal adhesion kinase (FAK), mitogenactivated protein kinase kinase 1/2 (MEK1/2) and extracellular signalregulated kinase 1/2 (ERK1/2) in SCC cells on type â
collagen. The downregulation of integrin ß8 in integrin αv transfectants by its specific antisense oligonucleotide led to a decrease in type â
collagenstimulated activation of FAK and the MEK/ERK signaling pathway, and also suppressed the proliferation on type â
collagen and the invasiveness into type â
collagen gel. Moreover, the expression of integrin ß8 was induced following transfection with integrin αv cDNA. These results indicated that the overexpression of integrin αv induces integrin αvß8 heterodimer formation and the binding of integrin αvß8 to type â
collagen might enhance the proliferation and invasion of SCC cells via the activation of the MEK/ERK signaling pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Integrinas
/
Colágeno Tipo I
/
Integrina alfaV
Limite:
Humans
Idioma:
En
Revista:
Int J Oncol
Ano de publicação:
2014
Tipo de documento:
Article