TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period.
J Alzheimers Dis
; 44(1): 57-61, 2015.
Article
em En
| MEDLINE
| ID: mdl-25201778
ABSTRACT
We previously reported TOMM40 to be significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects at baseline and after one-year. In this longitudinal follow-up study of TOMM40 expression up to 2 years, we performed 6-monthly assessments for the first year and 2nd year blood sampling on 27 probable AD subjects compared with age- and gender-matched controls. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supported by confirmatory RT-PCR results. Our findings of consistently lower TOMM40 expression on longitudinal 2-year sampling support its potential role as a diagnostic blood AD biomarker.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Regulação para Baixo
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Doença de Alzheimer
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Aged
/
Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
J Alzheimers Dis
Ano de publicação:
2015
Tipo de documento:
Article