In situ monitoring of intracellular controlled drug release from mesoporous silica nanoparticles coated with pH-responsive charge-reversal polymer.
ACS Appl Mater Interfaces
; 6(20): 17446-53, 2014 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-25231082
ABSTRACT
Therapeutic platforms such as chemotherapy that respond to physical and biological stimuli are highly desirable for effective cancer therapy. In this study, pH-responsive charge-reversal, polymer-coated mesoporous silica nanoparticles [PAH-cit/APTES-MSNs; PAH-cit refers to poly(allylamine)-citraconic anhydride; APTES refers to (3-aminopropyl)triethoxysilane] were synthesized for application as drug-delivery systems for the treatment of malignant cells. Confocal laser scanning microscopy (CLSM) revealed that the PAH-cit/APTES-MSNs nanocomposite effectively delivered and released doxorubicin hydrochloride to the nucleus of HeLa (human cervical carcinoma) cells. Additionally, the real-time dynamic drug-release process was monitored by CLSM. The current pH-controlled-smart-release platform holds promise in drug-delivery and cancer therapy-related applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Dióxido de Silício
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Materiais Revestidos Biocompatíveis
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Preparações de Ação Retardada
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Espaço Intracelular
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Nanopartículas
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Liberação Controlada de Fármacos
Limite:
Humans
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Ano de publicação:
2014
Tipo de documento:
Article