Interleukin-18 induces retinal pigment epithelium degeneration in mice.

Ijima, Ryo; Kaneko, Hiroki; Ye, Fuxiang; Nagasaka, Yosuke; Takayama, Kei; Kataoka, Keiko; Kachi, Shu; Iwase, Takeshi; Terasaki, Hiroko

Ijima, Ryo; Kaneko, Hiroki; Ye, Fuxiang; Nagasaka, Yosuke; Takayama, Kei; Kataoka, Keiko; Kachi, Shu; Iwase, Takeshi; Terasaki, Hiroko.

Afiliação

Ijima R; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kaneko H; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ye F; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagasaka Y; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takayama K; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kataoka K; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kachi S; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Iwase T; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Terasaki H; Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Invest Ophthalmol Vis Sci ; 55(10): 6673-8, 2014 Sep 18.

Article em En | MEDLINE | ID: mdl-25237159

Assuntos

Interleucina-18/metabolismo; Degeneração Macular/patologia; Epitélio Pigmentado da Retina/patologia; Idoso; Idoso de 80 Anos ou mais; Animais; Caspase 3/metabolismo; Modelos Animais de Doenças; Feminino; Angiofluoresceinografia; Fundo de Olho; Humanos; Interleucina-18/administração & dosagem; Injeções Intravítreas; Degeneração Macular/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Proteínas Recombinantes/farmacologia; Epitélio Pigmentado da Retina/efeitos dos fármacos; Epitélio Pigmentado da Retina/metabolismo

Palavras-chave

age-related macular degeneration; interleukin-18; retinal pigment epithelium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-18 / Epitélio Pigmentado da Retina / Degeneração Macular Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Ano de publicação: 2014 Tipo de documento: Article

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