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The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders.
Yegin, Z A; Iyidir, Ö T; Demirtas, C; Suyani, E; Yetkin, I; Pasaoglu, H; Ilhan, Ç; Sucak, G T.
Afiliação
  • Yegin ZA; Department of Hematology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey. zeyneparzuyegin@gmail.com.
  • Iyidir ÖT; Department of Endocrinology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Demirtas C; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Suyani E; Department of Hematology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey.
  • Yetkin I; Department of Endocrinology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Pasaoglu H; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Ilhan Ç; Department of Hematology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey.
  • Sucak GT; Department of Hematology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey.
J Endocrinol Invest ; 38(3): 333-8, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25245337
ABSTRACT

PURPOSE:

Metabolic syndrome (MetS) is considered as a proinflammatory and prothrombotic state with atherogenic risk factors including dyslipidemia, obesity and glucose intolerance. Oxidative stress is a unifying basis of several disorders including diabetes mellitus (DM) and MetS. We therefore designed this cross-sectional study to investigate the potential interaction among iron metabolism, inflammation and endothelial plexus in MetS and DM patients.

METHODS:

A total of 62 patients [median age 54 (23-76) years; male/female 16/46] and 18 healthy controls [median age 38 (30-64) years; male/female 6/12] were included in the study. Patient population was classified as MetS (n = 30) and DM (n = 32).

RESULTS:

Leukocyte count (p = 0.002) and osteopontin (OPN) levels (p = 0.008) were significantly higher, while C-reactive protein (CRP) (p = 0.056) and IL-6 (p = 0.059) represented a relative increase in the patient group. Leptin, endothelin 1 (ET1), hepcidin, nitric oxide synthase (NOS), erythrocyte sedimentation rate (ESR), iron, transferrin saturation (TS) and ferritin levels were not significantly different between the patient and control groups. Endothelin 1 was found to be higher in the DM group compared to MetS group (p = 0.15, p = 0.049). Leukocyte count, leptin, hepcidin, OPN, NOS, IL-6, ESR, CRP, iron, TS and ferritin levels were not different between DM and MetS groups. A positive correlation was demonstrated between leptin and OPN (p = 0.001, r = 0.360), ferritin and hepcidin (p < 0.01, r = 0.633), IL-6 and CRP (p = 0.023, r = 0.319), leptin and NOS (p = 0.005, r = 0.309) and OPN and NOS (p < 0.001, r = 0.803). There was a negative correlation between hepcidin and NOS (p = 0.009, r = -0.289). When the study cohort was divided into two particular groups based on median ferritin and hepcidin levels, hepcidin (p = 0.002), ALT (p = 0.001) and LDL (p = 0.049) levels were higher in the high-ferritin group. Nitric oxide synthase levels (p = 0.033) were lower, whereas ferritin levels (p = 0.004) were higher in the high-hepcidin group.

CONCLUSION:

Mechanisms involved in the vicious circle of MetS including inflammation, endothelial vasculature and iron metabolism remain to be elucidated. The role of iron metabolism in this complex interaction should be confirmed with further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Estresse Oxidativo / Síndrome Metabólica / Diabetes Mellitus / Ferro Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Endocrinol Invest Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Estresse Oxidativo / Síndrome Metabólica / Diabetes Mellitus / Ferro Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Endocrinol Invest Ano de publicação: 2015 Tipo de documento: Article