Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats.
J Ethnopharmacol
; 157: 45-54, 2014 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-25256690
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE The hip of Rosa multiflora Thunb. (HRM) has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases, including inflammation, osteoarthritis, rheumatoid arthritis and chronic pain, in China. The current study was to evaluate the therapeutic efficacy of the petroleum ether extractive of HRM (PEE) on type II collagen-induced rheumatoid arthritis (CIA) in male Wistar rats. In addition, the anti-inflammatory mechanism(s) of PEE on type II CIA was explored. MATERIALS AND METHODS:
Rheumatoid arthritis (RA) was induced by intradermal injection of bovine type II collagen on Day 1 and Day 8. Starting from Day 13, normal rats were treated with vehicle (serving as the control group); the CIA rats were treated with vehicle (CIA group), dexamethasone (0.25mg/kg bw per day, p.o.) (a positive control), lei-gong-teng (LGT 10mg/kg bw per day, p.o.) (a clinically used Chinese patent medicine in RA therapy) or PEE (12, 36 or 120mg/kg bw per day, p.o.) for 28 days. RESULTS ANDCONCLUSIONS:
PEE (120mg/kg bw per day) efficiently attenuated the severity of arthritis in the CIA rats by reducing the mean arthritis severity scores and the fore/hind paw swelling as well as reduced histological changes by decreasing the cartilage surface erosion and cartilage proteoglan depletion. PEE׳s therapeutic effect in RA may involve the inhibition of pro-inflammatory cytokines, such as TNF-α, IL-1ß and IL-6, in serum and/or the elevation of the activities of hepatic anti-oxidative enzymes including SOD, CAT and GSH-Px. However, the detailed anti-inflammatory mechanism, the main effective components and the interaction between different ingredients in PEE are still not clear and require more studies.Palavras-chave
17-pentatriacontene (PubChem CID 5365022); Autoimmune disease; Chinese medicinal herb; Heptadecane (PubChem CID: 12398); Hip of Rosa multiflora Thunb.; Nonacosane (PubChem CID: 12409); Rheumatoid arthritis; Tumor necrosis factor-α; Vitamin E (PubChem CID: 14985); linoleic acid (PubChem CID 5280450)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
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Artrite Reumatoide
/
Extratos Vegetais
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Rosa
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2014
Tipo de documento:
Article