Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.

Rhoo, Kun Hyoe; Granger, Megan; Sur, Joynita; Feng, Changyong; Gelbard, Harris A; Dewhurst, Stephen; Polesskaya, Oksana

Rhoo, Kun Hyoe; Granger, Megan; Sur, Joynita; Feng, Changyong; Gelbard, Harris A; Dewhurst, Stephen; Polesskaya, Oksana.

Afiliação

Rhoo KH; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.
Granger M; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.
Sur J; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.
Feng C; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States of America.
Gelbard HA; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America; Center for Neural Development and Disease, and Departments of Pediatrics and Neurology, University of Rochester Medical Center, Rochester, New York, United States of Amer
Dewhurst S; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.
Polesskaya O; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America.

PLoS One ; 9(9): e108487, 2014.

Article em En | MEDLINE | ID: mdl-25264786

Assuntos

Neoplasias Encefálicas/secundário; Neoplasias da Mama/patologia; Movimento Celular/efeitos dos fármacos; MAP Quinase Quinase Quinases/antagonistas & inibidores; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Feminino; Camundongos; Camundongos Nus; Transplante de Neoplasias; Inibidores de Proteínas Quinases/farmacologia; Piridinas/farmacologia; Pirróis/farmacologia; Transplante Heterólogo; MAP Quinase Quinase Quinase 11 Ativada por Mitógeno

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Neoplasias da Mama / Movimento Celular / MAP Quinase Quinase Quinases Limite: Animals Idioma: En Revista: PLoS One Ano de publicação: 2014 Tipo de documento: Article

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