Mitochondrial membrane potential and reactive oxygen species in cancer stem cells.
Fam Cancer
; 14(1): 19-23, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25266577
ABSTRACT
Cancer stem cells (CSCs) are believed as the initiators of the occurrence, development and recurrence of malignant tumors. Targeting this unique cell population would provide a less toxic approach than regular chemotherapeutic agents that kill bulk rapid proliferating tumor cells and also normal cells which divide rapidly. To date, major research effort has been aimed at identifying and eradicating CSC population. The metabolism heterogeneity of mitochondria in CSCs shows a big promise for cancer research. Of them, mitochondrial membrane potential (Δψm), reflecting the functional status of the mitochondrion is proved to be highly related to cancer malignancy. Reactive oxygen species, mainly produced from mitochondria, are also increased in many types of cancer cells. However, their statuses in CSCs remain poorly understood. Here we shall review the mitochondrial membrane potential and reactive oxygen species of CSCs and propose the novel potential targets for cancer therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Espécies Reativas de Oxigênio
/
Potencial da Membrana Mitocondrial
Limite:
Humans
Idioma:
En
Revista:
Fam Cancer
Ano de publicação:
2015
Tipo de documento:
Article