Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition.
Org Biomol Chem
; 12(43): 8607-10, 2014 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-25272305
ABSTRACT
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary-tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Quinina
/
Fluorocarbonos
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2014
Tipo de documento:
Article