Liposome encapsulated Disulfiram inhibits NF&#954;B pathway and targets breast cancer stem cells in vitro and in vivo.

Liu, Peng; Wang, Zhipeng; Brown, Sarah; Kannappan, Vinodh; Tawari, Patricia Erebi; Jiang, Wenguo; Irache, Juan M; Tang, James Z; Armesilla, Angel L; Darling, John L; Tang, Xing; Wang, Weiguang

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.

Liu, Peng; Wang, Zhipeng; Brown, Sarah; Kannappan, Vinodh; Tawari, Patricia Erebi; Jiang, Wenguo; Irache, Juan M; Tang, James Z; Armesilla, Angel L; Darling, John L; Tang, Xing; Wang, Weiguang.

Afiliação

Liu P; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Wang Z; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Brown S; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Kannappan V; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Tawari PE; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Jiang W; Cardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, UK.
Irache JM; School of Pharmacy, University of Navarra, Pamplona, Spain.
Tang JZ; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Armesilla AL; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Darling JL; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.
Tang X; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Wang W; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK.

Oncotarget ; 5(17): 7471-85, 2014 Sep 15.

Article em En | MEDLINE | ID: mdl-25277186

Assuntos

Antineoplásicos/administração & dosagem; Neoplasias da Mama/patologia; Dissulfiram/administração & dosagem; NF-kappa B/efeitos dos fármacos; Células-Tronco Neoplásicas/efeitos dos fármacos; Animais; Western Blotting; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Ensaio de Desvio de Mobilidade Eletroforética; Feminino; Citometria de Fluxo; Imunofluorescência; Xenoenxertos; Humanos; Imuno-Histoquímica; Marcação In Situ das Extremidades Cortadas; Lipossomos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; NF-kappa B/metabolismo; Células-Tronco Neoplásicas/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / NF-kappa B / Dissulfiram / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2014 Tipo de documento: Article

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