Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis.
Cancers (Basel)
; 6(4): 2049-71, 2014 Oct 02.
Article
em En
| MEDLINE
| ID: mdl-25279451
ABSTRACT
This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Cancers (Basel)
Ano de publicação:
2014
Tipo de documento:
Article