A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology.
Reprod Biol Endocrinol
; 12: 95, 2014 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-25280580
ABSTRACT
Gonadotropins extracted from the urine of post-menopausal women have traditionally been used to stimulate folliculogenesis in the treatment of infertility and in assisted reproductive technology (ART). Products, such as human menopausal gonadotropin (hMG), consist not only of a mixture of the hormones, follicle-stimulating hormone (FSH), luteinising hormone (LH) and human chorionic gonadotropin (hCG), but also other biologically active contaminants, such as growth factors, binding proteins and prion proteins. The actual amount of molecular LH in hMG preparations varies considerably due to the purification process, thus hCG, mimicking LH action, is added to standardise the product. However, unlike LH, hCG plays a different role during the natural human menstrual cycle. It is secreted by the embryo and placenta, and its main role is to support implantation and pregnancy. More recently, recombinant gonadotropins (r-hFSH and r-hLH) have become available for ART therapies. Recombinant LH contains only LH molecules. In the field of reproduction there has been controversy in recent years over whether r-hLH or hCG should be used for ART. This review examines the existing evidence for molecular and functional differences between LH and hCG and assesses the clinical implications of hCG-supplemented urinary therapy compared with recombinant therapies used for ART.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Hormônio Luteinizante
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Medicina Baseada em Evidências
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Técnicas de Reprodução Assistida
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Fármacos para a Fertilidade Feminina
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Gonadotropina Coriônica
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Infertilidade Feminina
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Reprod Biol Endocrinol
Ano de publicação:
2014
Tipo de documento:
Article