Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice.

Park, Min Jung; Aja, Susan; Li, Qun; Degano, Alicia L; Penati, Judith; Zhuo, Justin; Roe, Charles R; Ronnett, Gabriele V

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice.

Park, Min Jung; Aja, Susan; Li, Qun; Degano, Alicia L; Penati, Judith; Zhuo, Justin; Roe, Charles R; Ronnett, Gabriele V.

Afiliação

Park MJ; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Aja S; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Li Q; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Degano AL; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Departamento de Química Biológica, CIQUIBI
Penati J; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Zhuo J; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Roe CR; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America.
Ronnett GV; The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neurology, The Johns Hopkins

PLoS One ; 9(10): e109527, 2014.

Article em En | MEDLINE | ID: mdl-25299635

Assuntos

Ciclo do Ácido Cítrico/efeitos dos fármacos; Longevidade/efeitos dos fármacos; Proteína 2 de Ligação a Metil-CpG/genética; Atividade Motora/efeitos dos fármacos; Síndrome de Rett/dietoterapia; Triglicerídeos/administração & dosagem; Animais; Comportamento Animal/efeitos dos fármacos; Ciclo do Ácido Cítrico/genética; Dieta; Modelos Animais de Doenças; Expressão Gênica; Humanos; Metabolismo dos Lipídeos/efeitos dos fármacos; Masculino; Metaboloma/efeitos dos fármacos; Proteína 2 de Ligação a Metil-CpG/deficiência; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fenótipo; Síndrome de Rett/genética; Síndrome de Rett/fisiopatologia; Síndrome de Rett/psicologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Síndrome de Rett / Ciclo do Ácido Cítrico / Proteína 2 de Ligação a Metil-CpG / Longevidade / Atividade Motora Limite: Animals / Humans / Male Idioma: En Revista: PLoS One Ano de publicação: 2014 Tipo de documento: Article

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