Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak.

Sun, Jian-guo; Xiang, Jun; Zeng, Xue-li; Li, Xia; Wu, Ping; Fung, Kwok Pui; Liu, Fei-yan

Sun, Jian-guo; Xiang, Jun; Zeng, Xue-li; Li, Xia; Wu, Ping; Fung, Kwok Pui; Liu, Fei-yan.

Afiliação

Sun JG; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China; Joint Centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zhejiang University, Zijinggang Ca
Xiang J; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China.
Zeng XL; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China.
Li X; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China.
Wu P; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China; Joint Centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zhejiang University, Zijinggang Ca
Fung KP; Joint Centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zhejiang University, Zijinggang Campus, Hangzhou, China; School of Biomedical Sciences (SBS)v, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Liu FY; Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Zijinggang Campus, Hangzhou, China; Joint Centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zhejiang University, Zijinggang Ca

Cancer Lett ; 355(2): 253-63, 2014 Dec 28.

Article em En | MEDLINE | ID: mdl-25304383

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Apoptose/efeitos dos fármacos; Compostos de Bifenilo/farmacologia; Neoplasias do Colo/tratamento farmacológico; Proteína de Sequência 1 de Leucemia de Células Mieloides/metabolismo; Nitrofenóis/farmacologia; Nucleosídeos de Pirimidina/farmacologia; Sulfonamidas/farmacologia; Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo; Animais; Compostos de Bifenilo/administração & dosagem; Células CACO-2; Linhagem Celular Tumoral; Permeabilidade da Membrana Celular/efeitos dos fármacos; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Células HCT116; Humanos; Camundongos; Camundongos Nus; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Nitrofenóis/administração & dosagem; Piperazinas/administração & dosagem; Piperazinas/farmacologia; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Nucleosídeos de Pirimidina/administração & dosagem; Distribuição Aleatória; Sulfonamidas/administração & dosagem; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ABT-737; Apoptosis; Bak; Clitocine; Mcl-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleosídeos de Pirimidina / Sulfonamidas / Compostos de Bifenilo / Protocolos de Quimioterapia Combinada Antineoplásica / Apoptose / Neoplasias do Colo / Proteína Killer-Antagonista Homóloga a bcl-2 / Proteína de Sequência 1 de Leucemia de Células Mieloides / Nitrofenóis Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2014 Tipo de documento: Article

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