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Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.
Baud, Matthias G J; Lin-Shiao, Enrique; Cardote, Teresa; Tallant, Cynthia; Pschibul, Annica; Chan, Kwok-Ho; Zengerle, Michael; Garcia, Jordi R; Kwan, Terence T-L; Ferguson, Fleur M; Ciulli, Alessio.
Afiliação
  • Baud MGJ; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Lin-Shiao E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Cardote T; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Tallant C; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Pschibul A; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Chan KH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Zengerle M; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Garcia JR; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Kwan TT; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Ferguson FM; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK.
  • Ciulli A; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Science ; 346(6209): 638-641, 2014 Oct 31.
Article em En | MEDLINE | ID: mdl-25323695
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Sondas Moleculares / Engenharia de Proteínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Science Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Sondas Moleculares / Engenharia de Proteínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Science Ano de publicação: 2014 Tipo de documento: Article