Diarylethene based fluorescent switchable probes for the detection of amyloid-ß pathology in Alzheimer's disease.

Lv, Guanglei; Cui, Baiping; Lan, Haichuang; Wen, Ying; Sun, Anyang; Yi, Tao

Lv, Guanglei; Cui, Baiping; Lan, Haichuang; Wen, Ying; Sun, Anyang; Yi, Tao.

Afiliação

Lv G; Department of Chemistry & Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China. yitao@fudan.edu.cn.

Chem Commun (Camb) ; 51(1): 125-8, 2015 Jan 04.

Article em En | MEDLINE | ID: mdl-25384304

ABSTRACT

ABSTRACT

Two fluorescent switchable diarylethene derivatives which exhibit high affinity for amyloid-ß aggregates with the increase of fluorescence intensity were reported. Moreover, the probes show excellent photochromic and anti-photobleaching properties both in vitro and in vivo.

Assuntos

Peptídeos beta-Amiloides/análise; Corantes Fluorescentes/química; Microscopia de Fluorescência; Doença de Alzheimer/patologia; Encéfalo/metabolismo; Encéfalo/patologia; Curcumina/química; Corantes Fluorescentes/síntese química; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Corantes Fluorescentes / Microscopia de Fluorescência Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2015 Tipo de documento: Article

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