Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli.

Spisni, Enzo; Valerii, Maria C; De Fazio, Luigia; Cavazza, Elena; Borsetti, Francesca; Sgromo, Annamaria; Candela, Marco; Centanni, Manuela; Rizello, Fernando; Strillacci, Antonio

Spisni, Enzo; Valerii, Maria C; De Fazio, Luigia; Cavazza, Elena; Borsetti, Francesca; Sgromo, Annamaria; Candela, Marco; Centanni, Manuela; Rizello, Fernando; Strillacci, Antonio.

Afiliação

Spisni E; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.
Valerii MC; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.
De Fazio L; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.
Cavazza E; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.
Borsetti F; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.
Sgromo A; 1] Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy [2] Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Candela M; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Centanni M; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Rizello F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Strillacci A; Department of Biological, Geological and Environmental Sciences, Biology Unit, University of Bologna, Bologna, Italy.

Mol Ther ; 23(2): 278-89, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25393372

Assuntos

Colite/genética; Ciclo-Oxigenase 2/genética; Inativação Gênica; Técnicas de Transferência de Genes; Animais; Colite/induzido quimicamente; Colite/metabolismo; Colite/patologia; Colite/terapia; Modelos Animais de Doenças; Regulação para Baixo; Escherichia coli/genética; Escherichia coli/metabolismo; Microbioma Gastrointestinal; Expressão Gênica; Terapia Genética; Mucosa Intestinal/metabolismo; Mucosa Intestinal/microbiologia; Mucosa Intestinal/patologia; Camundongos; Interferência de RNA; RNA Mensageiro/genética; RNA Interferente Pequeno/genética

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Colite / Técnicas de Transferência de Genes / Inativação Gênica / Ciclo-Oxigenase 2 Limite: Animals Idioma: En Revista: Mol Ther Ano de publicação: 2015 Tipo de documento: Article

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