Reprogramming of prostate cancer cells--technical challenges.
Curr Urol Rep
; 16(1): 468, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25404182
ABSTRACT
Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Células-Tronco Neoplásicas
/
Reprogramação Celular
/
Desdiferenciação Celular
/
Células-Tronco Pluripotentes Induzidas
Limite:
Humans
/
Male
Idioma:
En
Revista:
Curr Urol Rep
Ano de publicação:
2015
Tipo de documento:
Article