A unified lead-oriented synthesis of over fifty molecular scaffolds.
Org Biomol Chem
; 13(3): 859-65, 2015 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-25408068
ABSTRACT
Controlling the properties of lead molecules is critical in drug discovery, but sourcing large numbers of lead-like compounds for screening collections is a major challenge. A unified synthetic approach is described that enabled the synthesis of 52 diverse lead-like molecular scaffolds from a minimal set of 13 precursors. The divergent approach exploited a suite of robust, functional group-tolerant transformations. Crucially, after derivatisation, these scaffolds would target significant lead-like chemical space, and complement commercially-available compounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbonatos
/
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
/
Aminas
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2015
Tipo de documento:
Article