Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.
ACS Comb Sci
; 17(1): 24-31, 2015 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-25412896
ABSTRACT
An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Naftiridinas
/
Antineoplásicos
Idioma:
En
Revista:
ACS Comb Sci
Ano de publicação:
2015
Tipo de documento:
Article