[High fat diet-induced molecular and physiological dysfunction of the urinary bladder]. / Hochfettdiät induziert molekulare und physiologische Dysfunktionen der Harnblase.
Urologe A
; 53(12): 1805-11, 2014 Dec.
Article
em De
| MEDLINE
| ID: mdl-25412909
ABSTRACT
BACKGROUND:
Obesity with its multiple comorbidities has become a global pandemia. We here report on the pathophysiological aspects of obesity-associated urinary bladder dysfunctions. MATERIAL ANDMETHODS:
Our results are based on multiple in vitro and in vivo studies including a high fat diet (HFD) rat animal model of which the details are given in the cited publications.RESULTS:
In cultured human detrusor muscle cells, obesity-related pathophysiological mechanisms were directly induced by the saturated free fatty acid palmitate. In HFD animals, we found serious fibrosis of the bladder wall and downregulation of the muscarinic M3-receptor leading to diminished contractility of the urinary bladder. Bariatric surgical intervention (sleeve gastrectomy) reversed the fibrosis.CONCLUSION:
Our results support the relevance of obesity for urological bladder dysfunction. The epidemic dimension of obesity with its steadily growing number of cases requires a re-evaluation of this pathological condition in the urological context.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Doenças da Bexiga Urinária
/
Proteoma
/
Obesidade
Limite:
Animals
/
Humans
Idioma:
De
Revista:
Urologe A
Ano de publicação:
2014
Tipo de documento:
Article