Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.
Immunobiology
; 220(1): 20-5, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25446398
ABSTRACT
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in redox stress pathway could augment the risk in NPC-susceptible individuals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Neoplasias Nasofaríngeas
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Estresse Oxidativo
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Predisposição Genética para Doença
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Immunobiology
Ano de publicação:
2015
Tipo de documento:
Article