Cocaine-induced sensitization correlates with testosterone in male Japanese quail but not with estradiol in female Japanese quail.
Horm Behav
; 67: 21-7, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25456105
ABSTRACT
Research has indicated that gonadal hormones may mediate behavioral and biological responses to cocaine. Estrogen, in particular, has been shown to increase behavioral responding to cocaine in female rats relative to male rats. The current study investigated the effect of cocaine on locomotor activity and hormonal correlates in male and female Japanese quail (Coturnix japonica). In Japanese quail, circulating hormone levels can be manipulated without surgical alterations via modifying the photoperiod. Male and female quail were housed on either 8L16D (lightdark) or 16L8D (lightdark) cycle for 21days. Blood samples were taken prior to the beginning of the experiment and assays were performed to determine the levels of testosterone (T) and estradiol (E2). Quail were given injections of saline or cocaine (10 or 20mg/kg) once a day for 10days. Immediately after each injection, birds were placed in open field arenas and distance traveled was measured for 30min. Results showed that male quail housed under long-light conditions exhibited cocaine-induced sensitization to 10mg/kg cocaine which was correlated with the high levels of plasma T. Female quail housed under short-light conditions demonstrated sensitization to 10mg/kg cocaine, but this was not correlated with the levels of plasma E2. The current findings suggest that cocaine-induced locomotor activity was associated with T in males but not with E2 in females.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
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Comportamento Animal
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Cocaína
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Coturnix
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Estradiol
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Sensibilização do Sistema Nervoso Central
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Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Horm Behav
Ano de publicação:
2015
Tipo de documento:
Article