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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E; Åkerblom, Eva; Svensson, Richard; Artursson, Per; Danielson, U Helena; Karlén, Anders; Sandström, Anja.
Afiliação
  • Lampa A; Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden.
  • Alogheli H; Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden.
  • Ehrenberg AE; Department of Chemistry-BMC, Uppsala University, BMC, Box 576, SE-751 23 Uppsala, Sweden.
  • Åkerblom E; Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden.
  • Svensson R; Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden; The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Uppsala University, A Node of the Chemical Biology Consortium Sweden (CBCS), Box 580, SE-751 23 Uppsala, Sweden.
  • Artursson P; Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden; The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Uppsala University, A Node of the Chemical Biology Consortium Sweden (CBCS), Box 580, SE-751 23 Uppsala, Sweden.
  • Danielson UH; Department of Chemistry-BMC, Uppsala University, BMC, Box 576, SE-751 23 Uppsala, Sweden.
  • Karlén A; Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden.
  • Sandström A; Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden. Electronic address: anja.sandstrom@orgfarm.uu.se.
Bioorg Med Chem ; 22(23): 6595-6615, 2014 Dec 01.
Article em En | MEDLINE | ID: mdl-25456385
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Pirimidinas / Proteínas de Transporte / Proteínas não Estruturais Virais / Compostos Macrocíclicos / Dipeptídeos Limite: Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Pirimidinas / Proteínas de Transporte / Proteínas não Estruturais Virais / Compostos Macrocíclicos / Dipeptídeos Limite: Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2014 Tipo de documento: Article