Segregação de Cromossomos/efeitos dos fármacos; Fluoruracila/farmacologia; Schizosaccharomyces/metabolismo; Cromátides/metabolismo; Regulação para Baixo/efeitos dos fármacos; Heterocromatina/metabolismo; Histonas/metabolismo; Cinetocoros/metabolismo; Metilação; Schizosaccharomyces/genética; Proteínas de Schizosaccharomyces pombe/metabolismo

5FU, 5'-Fluorouracil, 5FU; 5'-Fluorouracil; Anticancer drug; CENP-A, centromere-associated protein A; CLRC, Clr4 methyltransferase complex; ChIP, chromatin immunoprecipitation; FUTP, fluorouridine triphosphate; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluorodeoxyuridine triphosphate; G1 phase, gap 1 phase of cell cycle; GO, Gene Ontology; H3K9me, H3 lysine 9 methylation; HAT, histone acetyltransferase; HDAC, histone deacetylase; HMT, histone methyltransferase; HP1, heterochromatin protein 1; HULC, histone H2B ubiquitin ligase complex; MNAse, micrococcal nuclease; RDRC, RNA-directed RNA polymerase complex; RITS, RNA-induced transcriptional silencing; RNAi, interference RNA; S phase, synthesis phase of cell cycle; Schizosaccharomyces pombe; TBZ, thiabendazole; centromere; chromosome organization; chromosome segregation; cnt, central core; dsRNA, double-stranded RNA; heterochromatin; histone modification; imr, innermost repeats; siRNA, small interfering RNA