Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

Hostettler, Katrin E; Zhong, Jun; Papakonstantinou, Eleni; Karakiulakis, George; Tamm, Michael; Seidel, Petra; Sun, Qingzhu; Mandal, Jyotshna; Lardinois, Didier; Lambers, Christopher; Roth, Michael

Hostettler, Katrin E; Zhong, Jun; Papakonstantinou, Eleni; Karakiulakis, George; Tamm, Michael; Seidel, Petra; Sun, Qingzhu; Mandal, Jyotshna; Lardinois, Didier; Lambers, Christopher; Roth, Michael.

Afiliação

Hostettler KE; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. katrin.hostettler@usb.ch.
Zhong J; Clinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, Basel, 4031, Switzerland. katrin.hostettler@usb.ch.
Papakonstantinou E; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. Jun.zhong@unibas.ch.
Karakiulakis G; Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. epap@med.auth.gr.
Tamm M; Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. gkaraki@med.auth.gr.
Seidel P; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. michael.tamm@usb.ch.
Sun Q; Clinics of Respiratory Medicine, University Hospital Basel, Petersgraben 4, Basel, 4031, Switzerland. michael.tamm@usb.ch.
Mandal J; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. petra.seidel@unibas.ch.
Lardinois D; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. qingzhu.sun@unibas.ch.
Lambers C; Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel, Basel, 4031, Switzerland. jyotshna.mandal@usb.ch.
Roth M; Clinics of Thoracic Surgery, University Hospital Basel, Basel, 4031, Switzerland. didier.lardinois@usb.ch.

Respir Res ; 15: 157, 2014 Dec 12.

Article em En | MEDLINE | ID: mdl-25496490

Assuntos

Fibroblastos/efeitos dos fármacos; Fibrose Pulmonar Idiopática/enzimologia; Indóis/farmacologia; Pulmão/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Becaplermina; Estudos de Casos e Controles; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Precursores Enzimáticos/metabolismo; Matriz Extracelular/metabolismo; Fator 2 de Crescimento de Fibroblastos/farmacologia; Fibroblastos/enzimologia; Fibroblastos/patologia; Gelatinases/metabolismo; Humanos; Fibrose Pulmonar Idiopática/patologia; Pulmão/enzimologia; Pulmão/patologia; Fosforilação; Proteínas Proto-Oncogênicas c-sis/farmacologia; Receptores de Fatores de Crescimento de Fibroblastos/efeitos dos fármacos; Receptores de Fatores de Crescimento de Fibroblastos/metabolismo; Receptores do Fator de Crescimento Derivado de Plaquetas/efeitos dos fármacos; Receptores do Fator de Crescimento Derivado de Plaquetas/metabolismo; Receptores de Fatores de Crescimento do Endotélio Vascular/efeitos dos fármacos; Receptores de Fatores de Crescimento do Endotélio Vascular/metabolismo; Inibidor Tecidual de Metaloproteinase-2/metabolismo; Fator A de Crescimento do Endotélio Vascular/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Fibrose Pulmonar Idiopática / Fibroblastos / Indóis / Pulmão Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Respir Res Ano de publicação: 2014 Tipo de documento: Article

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