Short-term inhibition of 11ß-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice.

Wheelan, Nicola; Webster, Scott P; Kenyon, Christopher J; Caughey, Sarah; Walker, Brian R; Holmes, Megan C; Seckl, Jonathan R; Yau, Joyce L W

Wheelan, Nicola; Webster, Scott P; Kenyon, Christopher J; Caughey, Sarah; Walker, Brian R; Holmes, Megan C; Seckl, Jonathan R; Yau, Joyce L W.

Afiliação

Wheelan N; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, UK; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Webster SP; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Kenyon CJ; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Caughey S; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, UK; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Walker BR; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Holmes MC; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, UK; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Seckl JR; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, UK; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK.
Yau JL; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, UK; Endocrinology Unit, BHF Centre for Cardiovascular Science, University of Edinburgh, UK. Electronic address: Joyce.Yau@ed.ac.uk.

Neuropharmacology ; 91: 71-6, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25497454

Assuntos

11-beta-Hidroxiesteroide Desidrogenase Tipo 1/fisiologia; Medo/fisiologia; Memória/fisiologia; Memória Espacial/fisiologia; 11-beta-Hidroxiesteroide Desidrogenase Tipo 1/antagonistas & inibidores; Fatores Etários; Animais; Condicionamento Clássico/efeitos dos fármacos; Condicionamento Clássico/fisiologia; Corticosterona/sangue; Estudos Cross-Over; Medo/efeitos dos fármacos; Masculino; Memória/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Pirazóis/farmacologia; Memória Espacial/efeitos dos fármacos; Tiofenos/farmacologia

Palavras-chave

Corticosterone; Fear conditioning; Hippocampus; Spatial memory; Y-maze

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / Medo / Memória Espacial / Memória Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2015 Tipo de documento: Article

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