The notochord breaks bilateral symmetry by controlling cell shapes in the zebrafish laterality organ.
Dev Cell
; 31(6): 774-83, 2014 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-25535919
ABSTRACT
Kupffer's vesicle (KV) is the zebrafish organ of laterality, patterning the embryo along its left-right (LR) axis. Regional differences in cell shape within the lumen-lining KV epithelium are essential for its LR patterning function. However, the processes by which KV cells acquire their characteristic shapes are largely unknown. Here, we show that the notochord induces regional differences in cell shape within KV by triggering extracellular matrix (ECM) accumulation adjacent to anterior-dorsal (AD) regions of KV. This localized ECM deposition restricts apical expansion of lumen-lining epithelial cells in AD regions of KV during lumen growth. Our study provides mechanistic insight into the processes by which KV translates global embryonic patterning into regional cell shape differences required for its LR symmetry-breaking function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
/
Padronização Corporal
/
Forma Celular
/
Notocorda
Limite:
Animals
Idioma:
En
Revista:
Dev Cell
Ano de publicação:
2014
Tipo de documento:
Article