Thymoquinone attenuates trauma induced spinal cord damage in an animal model.
Ulus Travma Acil Cerrahi Derg
; 20(5): 328-32, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25541843
ABSTRACT
BACKGROUND:
Spinal cord injury (SCI) is one of the most devastating conditions leading to neurological impairment and disabilities. The aim of the study was to investigate the potential neuroprotective effect of thymoquinone (TQ) histopathologically in an experimental model of traumatic spinal cord injury (SCI).METHODS:
Twenty-four male Wistar albino rats were randomly divided into 4 groups control group; SCI group; SCI-induced and 10 mg/kg/day TQ administered group; SCI-induced and 30 mg/kg/day TQ administered group. TQ was given as intraperitoneal for three days prior to injury and four days following injury. Spinal cord segment between T8 and T10 were taken for histopathologic examination. Hemorrhage, spongiosis and liquefactive necrosis were analyzed semiquantatively for histopathological changes.RESULTS:
Administration of TQ at a dose of 10 mg/kg did not cause any significant change on the histological features of neuronal degeneration as compared to the SCI group (p=0.269); however, 30 mg/kg TQ significantly decreased the histological features of spinal cord damage below that of the SCI group (p=0.011).CONCLUSION:
Data from this study suggest that TQ supplementation attenuates trauma induced spinal cord damage. Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Benzoquinonas
/
Fármacos Neuroprotetores
Limite:
Animals
Idioma:
En
Revista:
Ulus Travma Acil Cerrahi Derg
Ano de publicação:
2014
Tipo de documento:
Article