Changes in Na,K-ATPase, sodium ion, and glucose transport in isolated enterocytes in an experimental model of malabsorption.
Dig Dis Sci
; 34(11): 1739-44, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2555121
ABSTRACT
Nippostrongylus brasiliensis infection of the rat resulted, at day 10 of infection, in decreased levels of jejunal enterocyte sodium-potassium-activated adenosine triphosphatase (Na,K-ATPase) and potassium-activated p-nitrophenyl phosphatase (K-pNPPase) activities. Parallel decreases occurred in active sodium efflux from jejunal enterocytes in the presence and absence of actively transported monosaccharides. Ileal enterocyte Na,K-ATPase and K-pNPPase activities were significantly increased, as was active sodium efflux. In contrast to controls, the presence of monosaccharides produced a stimulation of active sodium efflux from ileal enterocytes derived from infected rats. Enzyme and sodium transport changes in the jejunal enterocytes probably reflect cellular immaturity. Functional changes in ileal enterocytes probably represent a compensatory phenomenon.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
ATPase Trocadora de Sódio-Potássio
/
Glucose
/
Jejuno
/
Síndromes de Malabsorção
Limite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
1989
Tipo de documento:
Article