Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.

Turk, S R; Kik, N A; Birch, G M; Chiego, D J; Shipman, C

Turk, S R; Kik, N A; Birch, G M; Chiego, D J; Shipman, C.

Afiliação

Turk SR; Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109.

Virology ; 173(2): 733-5, 1989 Dec.

Article em En | MEDLINE | ID: mdl-2556851

ABSTRACT

ABSTRACT

Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.

Assuntos

Herpes Simples/microbiologia; Ribonucleotídeo Redutases/genética; Simplexvirus/genética; Animais; Linhagem Celular; Modelos Animais de Doenças; Feminino; Cobaias; Histocitoquímica; Mutação; Simplexvirus/enzimologia; Simplexvirus/fisiologia; Pele/patologia; Replicação Viral

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleotídeo Redutases / Simplexvirus / Herpes Simples Limite: Animals Idioma: En Revista: Virology Ano de publicação: 1989 Tipo de documento: Article

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