Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
J Exp Med
; 212(2): 235-52, 2015 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-25584011
ABSTRACT
Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary fibrosis is an epithelial-mesenchymal disorder in which TGF-ß1 plays a central role in pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-ß and bone morphogenetic protein signaling, leading to epithelial injury and fibroblast activation. Haplodeletion of Fstl1 in mice or blockage of FSTL1 with a neutralizing antibody in mice reduced bleomycin-induced fibrosis in vivo. Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Fibrose Pulmonar
/
Proteínas Relacionadas à Folistatina
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2015
Tipo de documento:
Article