Chronic systemic IL-1ß exacerbates central neuroinflammation independently of the blood-brain barrier integrity.
J Neuroimmunol
; 278: 30-43, 2015 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-25595250
ABSTRACT
Peripheral circulating cytokines are involved in immune to brain communication and systemic inflammation is considered a risk factor for flaring up the symptoms in most neurodegenerative diseases. We induced both central inflammatory demyelinating lesion, and systemic inflammation with an interleukin-1ß expressing adenovector. The peripheral pro-inflammatory stimulus aggravated the ongoing central lesion independently of the blood-brain barrier (BBB) integrity. This model allows studying the role of specific molecules and cells (neutrophils) from the innate immune system, in the relationship between central and peripheral communication, and on relapsing episodes of demyelinating lesions, along with the role of BBB integrity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Barreira Hematoencefálica
/
Sistema Nervoso Central
/
Interleucina-1beta
/
Inflamação
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2015
Tipo de documento:
Article