[Protective effect of epigallocatechin gallate against sperm abnormality in mice].
Zhonghua Nan Ke Xue
; 20(12): 1068-72, 2014 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-25597170
ABSTRACT
OBJECTIVE:
To investigate the protective effect of epigallocatechin gallate (EGCG) on mouse sperm in vivo.METHODS:
A total of 64 six-week-old male Kuming mice were randomly divided into eight groups of equal number to be treated with normal saline (negative control), Cyclophosphamide (CP) at 30 mg/kg (positive control), and CP followed by EGCG (experimental) at 20, 40, and 80 mg/kg, respectively, given every other day for 10 days. At 4 and 5 weeks after treatment, the bilateral testes of the mice were harvested for examination of sperm abnormality.RESULTS:
EGCG did not increase the rate of CP-induced sperm abnormality in the mice, but reduced it instead with the prolonged time of treatment.CONCLUSION:
EGCG protects mouse sperm in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Catequina
Limite:
Animals
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Ano de publicação:
2014
Tipo de documento:
Article