Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage.

Comeaux, Evan Q; Cuya, Selma M; Kojima, Kyoko; Jafari, Nauzanene; Wanzeck, Keith C; Mobley, James A; Bjornsti, Mary-Ann; van Waardenburg, Robert C A M

Comeaux, Evan Q; Cuya, Selma M; Kojima, Kyoko; Jafari, Nauzanene; Wanzeck, Keith C; Mobley, James A; Bjornsti, Mary-Ann; van Waardenburg, Robert C A M.

Afiliação

Comeaux EQ; From the Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Cuya SM; From the Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Kojima K; the University of Alabama at Birmingham Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Jafari N; Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, and.
Wanzeck KC; From the Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Mobley JA; the Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Bjornsti MA; From the Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
van Waardenburg RC; From the Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, rvanwaar@uab.edu.

J Biol Chem ; 290(10): 6203-14, 2015 Mar 06.

Article em En | MEDLINE | ID: mdl-25609251

Assuntos

Adutos de DNA/química; DNA/genética; Proteínas Mutantes/química; Diester Fosfórico Hidrolases/genética; Catálise; Domínio Catalítico/genética; Cristalografia por Raios X; DNA/química; Adutos de DNA/genética; Dano ao DNA/genética; Reparo do DNA/genética; DNA Topoisomerases Tipo I/química; DNA Topoisomerases Tipo I/genética; Humanos; Complexos Multiproteicos/química; Complexos Multiproteicos/genética; Proteínas Mutantes/genética; Diester Fosfórico Hidrolases/química; Ataxias Espinocerebelares/genética; Ataxias Espinocerebelares/patologia

Palavras-chave

DNA Damage; DNA Repair; DNA Topoisomerase; Enzyme Mechanism; Enzyme Mutation; Protein-DNA Covalent Complexes; Spinocerebellar Ataxia with Axonal Neuropathy 1; Tyrosyl-DNA Phosphodiesterase I

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Diester Fosfórico Hidrolases / Adutos de DNA / Proteínas Mutantes Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article

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