Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors.

Knippenberg, Sarah; Rath, Klaus Jan; Böselt, Sebastian; Thau-Habermann, Nadine; Schwarz, Sigrid C; Dengler, Reinhard; Wegner, Florian; Petri, Susanne

Knippenberg, Sarah; Rath, Klaus Jan; Böselt, Sebastian; Thau-Habermann, Nadine; Schwarz, Sigrid C; Dengler, Reinhard; Wegner, Florian; Petri, Susanne.

Afiliação

Knippenberg S; Department of Neurology, Hannover Medical School, Germany.
Rath KJ; Department of Neurology, Hannover Medical School, Germany.
Böselt S; Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.
Thau-Habermann N; Department of Neurology, Hannover Medical School, Germany.
Schwarz SC; Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.
Dengler R; Department of Neurology, Hannover Medical School, Germany.
Wegner F; Centre for Systems Neuroscience, Hannover, Germany.
Petri S; German Centre for Neurodegenerative Diseases (DZNE), Technical University of Munich, Germany.

J Tissue Eng Regen Med ; 11(3): 751-764, 2017 03.

Article em En | MEDLINE | ID: mdl-25641599

Assuntos

Esclerose Lateral Amiotrófica/terapia; Fatores de Crescimento Neural/metabolismo; Células-Tronco Neurais/transplante; Medula Espinal/citologia; Superóxido Dismutase/genética; Esclerose Lateral Amiotrófica/patologia; Esclerose Lateral Amiotrófica/fisiopatologia; Animais; Linhagem da Célula; Modelos Animais de Doenças; Progressão da Doença; Humanos; Injeções Espinhais; Camundongos Transgênicos; Atividade Motora; Células-Tronco Neurais/citologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transplante de Células-Tronco; Análise de Sobrevida

Palavras-chave

G93A-SOD1 mouse model; human neural progenitor cells; immunohistochemistry; intraspinal injection; motor function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Superóxido Dismutase / Células-Tronco Neurais / Esclerose Lateral Amiotrófica / Fatores de Crescimento Neural Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Tissue Eng Regen Med Ano de publicação: 2017 Tipo de documento: Article

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