Evaluation of bone involvement in patients with Gaucher disease: a semi-quantitative magnetic resonance imaging method (using ROI estimation of bone lesion) as an alternative method to semi-quantitative methods used so far.
Eur J Haematol
; 95(4): 342-51, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25645321
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate bone involvement in patients with Gaucher disease (GD) and to propose a novel semi-quantitative magnetic resonance imaging (MRI) staging.METHODS:
MRI of the lumbar spine, femur, and tibia was performed in 24 patients with GD and 24 healthy controls. We also measured circulating levels of C-C motif ligand-3 (CCL-3) chemokine, C-telopeptide of collagen type-1 (CTX), and tartrate-resistant acid phosphatase isoform type-b (TRACP-5b).RESULTS:
We used the following staging based on MRI data stage I region of interest (ROI) 1/2 of normal values and bone infiltration up to 30%; stage II ROI 1/3 of normal values and bone infiltration from 30 to 60%; stage III ROI 1/4 of normal values and bone infiltration from 60% to 80%; and stage IV detection of epiphyseal infiltration, osteonecrosis and deformity regardless of the ROI's values. All but two patients had abnormal MRIfindings:
9 (37.5%), 6 (25%), 3 (12.5%), and 4 (16.7%) had stages I-IV, respectively. Patients with GD had elevated chitotriosidase, serum TRACP-5b, and CCL-3 levels (P < 0.001).CONCLUSIONS:
We propose an easily reproducible semi-quantitative scoring system and confirm that patients with GD have abnormal MRI bone findings and enhanced osteoclast activity possibly due to elevated CCL-3.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Ósseas
/
Imageamento por Ressonância Magnética
/
Doença de Gaucher
Tipo de estudo:
Diagnostic_studies
Aspecto:
Patient_preference
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Haematol
Ano de publicação:
2015
Tipo de documento:
Article