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Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
Zhao, Baoyu; Gandhi, Sonu; Yuan, Cai; Luo, Zhipu; Li, Rui; Gårdsvoll, Henrik; de Lorenzi, Valentina; Sidenius, Nicolai; Huang, Mingdong; Ploug, Michael.
Afiliação
  • Zhao B; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Danish-Chinese Centre for Proteases and Cancer.
  • Gandhi S; Cell Matrix Signaling Unit, Institute of Molecular Oncology of the Italian Foundation for Cancer Research, via Adamello 16, 20139 Milan, Italy.
  • Yuan C; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Danish-Chinese Centre for Proteases and Cancer.
  • Luo Z; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Danish-Chinese Centre for Proteases and Cancer.
  • Li R; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Biotech Research and Innovation Centre, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen North, Denmark.
  • Gårdsvoll H; Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen North, Denmark; Biotech Research and Innovation Centre, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen North, Denmark; Danish-Chinese Centre for Proteases and Cancer.
  • de Lorenzi V; Cell Matrix Signaling Unit, Institute of Molecular Oncology of the Italian Foundation for Cancer Research, via Adamello 16, 20139 Milan, Italy.
  • Sidenius N; Cell Matrix Signaling Unit, Institute of Molecular Oncology of the Italian Foundation for Cancer Research, via Adamello 16, 20139 Milan, Italy.
  • Huang M; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Danish-Chinese Centre for Proteases and Cancer. Electronic address: mhuang@fjirsm.ac.cn.
  • Ploug M; Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen North, Denmark; Biotech Research and Innovation Centre, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen North, Denmark; Danish-Chinese Centre for Proteases and Cancer. Electronic address: m-plo
J Mol Biol ; 427(6 Pt B): 1389-1403, 2015 Mar 27.
Article em En | MEDLINE | ID: mdl-25659907
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conformação Proteica / Somatomedinas / Vitronectina / Receptores de Ativador de Plasminogênio Tipo Uroquinase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Mol Biol Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conformação Proteica / Somatomedinas / Vitronectina / Receptores de Ativador de Plasminogênio Tipo Uroquinase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Mol Biol Ano de publicação: 2015 Tipo de documento: Article