[Treatment of hepatic insufficiency in benign mechanical jaundice].
Klin Med (Mosk)
; 91(11): 53-6, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-25696967
ABSTRACT
The aim of this work was to estimate hepatic dysfunction and improve treatment of benign mechanical jaundice using an injection hepatoprotector. The study included 124 patients of whom 74 were given remaxol. 50 control subjects received basal therapy. The patients were randomized by the random sampling method. Severity of cholestasis was evaluated from the total and fractional bilirubin content and γ-glutamyl transpeptidase (GGT) level; AST and ALT activities were used to detect cytolysis. Liver synthetic function was estimated from prothrombin index (PTI) and coagulation function from fibrinogen level, PTI and APTT. Endogenous intoxication during biliary tract decompression was assessed by calculating the leukocyte intoxication index from the Kalf-Kalif formula. It was shown that remaxol suppresses cytolysis, reduces total and fractional bilirubin levels, improves bilirubin excretion in bile and decreases activity of hepatocyte excretory enzymes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinatos
/
Icterícia Obstrutiva
/
Insuficiência Hepática
/
Período Pré-Operatório
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
Idioma:
Ru
Revista:
Klin Med (Mosk)
Ano de publicação:
2013
Tipo de documento:
Article