Transfer of DOPA from the sympatho-adrenal system to the pancreas, liver and kidney via the blood circulation.
Acta Physiol Scand
; 136(1): 75-9, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2570506
ABSTRACT
The concentration of 3,4-dihydroxyphenylalanine (DOPA) was low in the pancreas, liver, kidney, spleen, salivary glands, heart and adrenal glands of untreated mice, but increased following inhibition of DOPA decarboxylase by 3-hydroxybenzylhydrazine. The ratio of the accumulation of DOPA to the concentration of noradrenaline (i.e. the density of sympathetic nerves) was greater in the kidney, liver and, particularly, pancreas than in the other organs studied, suggesting that DOPA occurred outside sympathetic nerves in these organs. The tyrosine hydroxylase inhibitor alpha-methyltyrosine almost completely inhibited the accumulation of DOPA in all organs. The DOPA accumulation was enhanced in all organs by the alpha-adrenoceptor antagonists phentolamine and yohimbine. The results indicate that the DOPA was formed in the sympatho-adrenal system. In the pancreas, liver and kidney, most of the DOPA accumulated might have been formed outside these organs and transferred there via the bloodstream.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Sistema Nervoso Simpático
/
Di-Hidroxifenilalanina
/
Glândulas Suprarrenais
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Scand
Ano de publicação:
1989
Tipo de documento:
Article