Targeting carbonic anhydrase IX with small organic ligands.
Curr Opin Chem Biol
; 26: 48-54, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25721398
ABSTRACT
Carbonic anhydrase IX (CAIX) is expressed in many solid tumors in response to hypoxia and plays an important role in tumor acid-base homeostasis under these conditions. It is also constitutively expressed in the majority of renal cell carcinoma. Its functional inhibition with small molecules has recently been shown to retard tumor growth in murine models of cancer, reduce metastasis and tumor stem cell expansion. Additionally, CAIX is a promising antigen for targeted drug delivery approaches. Initially validated with anti-CAIX antibodies, the tumor-homing capacity of high-affinity small-molecule ligands of CAIX has recently been demonstrated. Indeed, conjugates formed of CAIX ligands and potent cytotoxic drugs could eradicate CAIX-expressing solid tumors in mice. These results suggest that CAIX is a promising target for the development of novel therapies for the treatment of solid tumors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Anidrase Carbônica
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Neoplasias Colorretais
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Anidrases Carbônicas
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Bibliotecas de Moléculas Pequenas
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Acetazolamida
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Antígenos de Neoplasias
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Curr Opin Chem Biol
Ano de publicação:
2015
Tipo de documento:
Article