[Functions of microglia in the healthy brain: focus on neuroplasticity].
Usp Fiziol Nauk
; 45(4): 3-18, 2014.
Article
em Ru
| MEDLINE
| ID: mdl-25729841
ABSTRACT
Microglia is in the center of modern research because it is involved in neuroinflammation processes, which is considered as an important part of pathogenesis of many brain pathologies. On the contrary, normal physiological functions of microglia are less studied. Here we review modern data on functioning of microglia in the healthy brain. We consider involvement of microglia in angiogenesis, neurogenesis, synaptogenesis, long-term potentiation, and the mechanisms of microglia-neuron interaction. We further consider modern concept on active interaction of microglia with neurons in developing and healthy mature brain and the essential role of microglia in neuroplasticity mechanisms at various levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Microglia
/
Plasticidade Neuronal
Limite:
Humans
Idioma:
Ru
Revista:
Usp Fiziol Nauk
Ano de publicação:
2014
Tipo de documento:
Article