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Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials.
Hu, Xian-qing; Cheng, Jian; Tang, Biao; Zhang, Zhong-heng; Huang, Ke; Yang, Yi-ping; Mao, Yan-yan; Zhong, Ming; Fu, Shen-wen.
Afiliação
  • Hu XQ; Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China; Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China.
J Zhejiang Univ Sci B ; 16(3): 198-207, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25743121
ABSTRACT

OBJECTIVE:

To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).

METHODS:

Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model.

RESULTS:

Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care (risk ratio (RR) 0.533; 95% confidence intervals (CI) 0.368-0.770), whereas non-fatal reinfarction slightly increased in the postconditioning group (RR 2.746; 95% CI 1.007-7.488). No significant difference in total major adverse cardiac events (MACEs) was observed between the two groups (RR 0.876; 95% CI 0.671-1.144).

CONCLUSIONS:

Postconditioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Pós-Condicionamento Isquêmico / Intervenção Coronária Percutânea / Infarto do Miocárdio Tipo de estudo: Clinical_trials / Etiology_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: J Zhejiang Univ Sci B Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Pós-Condicionamento Isquêmico / Intervenção Coronária Percutânea / Infarto do Miocárdio Tipo de estudo: Clinical_trials / Etiology_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: J Zhejiang Univ Sci B Ano de publicação: 2015 Tipo de documento: Article