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Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
Hague, R V; May, W; Cullen, D R.
Afiliação
  • Hague RV; Department of Medicine, District General Hospital, Barnsley, UK.
Clin Endocrinol (Oxf) ; 31(1): 51-7, 1989 Jul.
Article em En | MEDLINE | ID: mdl-2574647
Two cases are described in which metastatic adrenocortical carcinoma associated with Cushing's syndrome was treated with mitotane (o,p'DDD). The first patient had initially been treated by bilateral adrenalectomy and, whilst responding to mitotane biochemically and by remission of metastases, experienced repeated episodes of adrenal crisis requiring a substantial increase in steroid therapy. The second patient failed to respond to the drug, but evidence of hepatic enzyme induction was noted during its administration. It is suggested that hepatic microsomal enzyme induction can occur in association with treatment with mitotane and that this can lead to an increased destruction of exogenous steroid with clinical consequences.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Doença de Addison / Carcinoma / Neoplasias do Córtex Suprarrenal / Mitotano Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Endocrinol (Oxf) Ano de publicação: 1989 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Doença de Addison / Carcinoma / Neoplasias do Córtex Suprarrenal / Mitotano Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Endocrinol (Oxf) Ano de publicação: 1989 Tipo de documento: Article