Soluble plasma VE-cadherin concentrations are elevated in patients with STEC infection and haemolytic uraemic syndrome: a case-control study.
BMJ Open
; 5(3): e005659, 2015 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-25757942
ABSTRACT
OBJECTIVES:
To investigate whether the adherens junction protein vascular endothelial cadherin (VE-cadherin) is released during Shiga toxin 2 producing Escherichia coli (STEC) infection with haemolytic uraemic syndrome (HUS) and thus could be used to assist diagnosis.DESIGN:
Using data from the large 2011 STEC outbreak in northern Europe, we determined VE-cadherin plasma concentrations in 356 patients distributed over three patient cohorts patients with STEC infection accompanied by HUS (STEC-HUS), STEC patients without HUS (STEC) and control patients with diarrhoea but without STEC infection. We then looked for associations between VE-cadherin concentrations and disease severity defined by changes in lactate dehydrogenase, haemoglobin, creatinine, platelet count, haptoglobin and neurological symptoms.SETTING:
This study was conducted at the University Medical Center Hamburg-Eppendorf, Germany.PARTICIPANTS:
79 STEC-HUS patients, 77 STEC patients and 200 control patients were enrolled in the study.RESULTS:
We analysed 864 specimens (207 STEC, 449 STEC-HUS and 208 controls) in total. At admission, VE-cadherin concentration tended to be lower in STEC-HUS patients compared to other patients. However, HUS patients later showed an increase in VE-cadherin concentrations with prolonged elevation beyond remission. This pattern clearly differs from that observed in non-HUS patients.CONCLUSIONS:
VE-cadherin concentrations are elevated in STEC-HUS patients and might be a biomarker reflecting endothelial damage in patients with HUS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
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3_ND
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
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Antígenos CD
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Caderinas
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Toxina Shiga II
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Infecções por Escherichia coli
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Escherichia coli Shiga Toxigênica
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Síndrome Hemolítico-Urêmica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Aged
/
Child
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Child, preschool
/
Female
/
Humans
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Infant
/
Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
BMJ Open
Ano de publicação:
2015
Tipo de documento:
Article