Synthesis of novel thiopurine pyranonucleosides: evaluation of their bioactivity.
Nucleosides Nucleotides Nucleic Acids
; 34(4): 289-308, 2015.
Article
em En
| MEDLINE
| ID: mdl-25774721
ABSTRACT
We report the synthesis of novel thiopurine pyranonucleosides. Direct coupling of silylated 6-mercaptopurine and 6-thioguanine with the appropriate pyranoses 1a-e via Vorbrüggen nucleosidation, gave the N-9 linked mercaptopurine 2a-e and thioguanine 4a-e nucleosides, while their N-7 substituted congeners 10a-e and 7a-e, were obtained through condensation of the same acetates with 6-chloro and 2-amino-6-chloropurines, followed by subsequent thionation. Nucleosides 3a-e, 5a-e, 8a-e, and 11a-e were evaluated for their cytostatic activity in three different tumor cell proliferative assays.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nucleosídeos de Purina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Ano de publicação:
2015
Tipo de documento:
Article