Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
PLoS One
; 10(3): e0120807, 2015.
Article
em En
| MEDLINE
| ID: mdl-25786110
ABSTRACT
Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis. PTX3 bound acapsular meningococcus, Neisseria-derived outer membrane vesicles (OMV) and 3 selected meningococcal antigens (GNA0667, GNA1030 and GNA2091). PTX3-recognized microbial moieties are conserved structures which fulfil essential microbial functions. Ptx3-deficient mice had a lower antibody response in vaccination protocols with OMV and co-administration of PTX3 increased the antibody response, particularly in Ptx3-deficient mice. Administration of PTX3 reduced the bacterial load in infant rats challenged with Neisseria meningitidis. These results suggest that PTX3 recognizes a set of conserved structures from Neisseria meningitidis and acts as an amplifier/endogenous adjuvant of responses to this bacterium.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Componente Amiloide P Sérico
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Adjuvantes Imunológicos
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Vacinas Meningocócicas
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Meningite Meningocócica
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Anticorpos Antibacterianos
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Antígenos de Bactérias
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Neisseria meningitidis
Limite:
Animals
Idioma:
En
Revista:
PLoS One
Ano de publicação:
2015
Tipo de documento:
Article